Table 1. Gene ontology (GO) analysis using differentially expressed genes (DEGs) observed in liver tissues of CTE versus PO groups

Term Count p-value
Cellular response to vascular endothelial growth factor stimulus 7 4.15E-05
Positive regulation of angiogenesis 14 9.51E-05
Sprouting angiogenesis 7 2.20E-04
Extrinsic apoptotic signaling pathway in absence of ligand 8 2.74E-04
Transmembrane receptor protein tyrosine kinase signaling pathway 11 0.001
Sterol biosynthetic process 6 0.001
Positive regulation of MAPK cascade 11 0.001
Negative regulation of endothelial cell apoptotic process 6 0.002
Positive regulation of endothelial cell migration 7 0.002
Cholesterol metabolic process 10 0.002
Steroid metabolic process 9 0.004
Neuron migration 11 0.005
Neutrophil chemotaxis 8 0.005
Oxidation-reduction process 34 0.007
Angiogenesis 16 0.008
T cell differentiation 6 0.008
Cell surface receptor signaling pathway 15 0.008
Lipid metabolic process 25 0.009
Response to drug 20 0.009
Receptor-mediated endocytosis 7 0.010
Neural tube patterning 3 0.013
Positive regulation of ERK1 and ERK2 cascade 13 0.014
Protein oligomerization 7 0.017
Apoptotic process 28 0.019
Single organismal cell-cell adhesion 9 0.019
Cellular response to insulin stimulus 8 0.019
Positive regulation of cell migration 13 0.024
Positive regulation of protein phosphorylation 12 0.028
Positive regulation of cell adhesion 6 0.029
Response to glucose 7 0.034
Response to hypoxia 12 0.037
Negative regulation of canonical Wnt signaling pathway 8 0.039
Steroid biosynthetic process 6 0.042
Potassium ion transport 9 0.044
Blood coagulation 7 0.046
Nervous system development 19 0.047
Positive regulation of phosphatidylinositol 3-kinase signaling 6 0.048