Table 3 Effects of orally administered DEHP, IOO, IOS and ATEC and subcutaneously administered TP on androgen-insensitive organ weights of castrated rats

Treatmenta	Kidney(mg)	Adrenal glands(mg)	Spleen(mg)	Liver(g)
INT	1,150.1±25.2	25.2±1.4	740.5±27.6	12.7±0.6
ORX	931.8±19.5	28.4±1.9	699.5±33.5	12.0±0.7
ORX+TP	1,169.8±13.8	28.2±1.3	822.8±56.5	12.1±0.8
DEHP-40	1,037.9±19.0***	25.7±0.7	715.8±54.7	11.1±0.4
DEHP-40+TP	1,190.4±37.1	22.5±1.0††	765.4±23.1	14.0±0.7
DEHP-400	1,178.6±19.1***	31.6±1.2	671.6±50.6	11.9±1.4
DEHP-400+TP	1,164.4±32.9	26.8±1.2	741.7±61.0	13.1±1.0
IOO-40	923.7±51.7	24.8±0.6	726.8±19.2	10.4±0.2*
IOO-40+TP	991.3±21.2†††	23.4±0.9††	747.8±49.2	10.1±0.3†
IOO-400	880.5±43.0	26.1±1.4	561.4±95.7*	8.3±1.0**
IOO-400+TP	986.6±20.4†††	19.5±1.1†††	737.1±53.1	11.3±0.3
IOS-40	967.3±15.9	26.4±1.2	761.3±37.1	10.1±0.4*
IOS-40+TP	1,064.5±22.7†††	27.4±0.7	821.0±28.3	11.2±0.3
IOS-400	978.2±22.8	31.8±1.8*	673.8±35.6	10.7±0.6
IOS-400+TP	1,080.7±28.3††	27.2±0.8	798.6±64.8	12.1±0.2
ATEC-40	1,046.8±20.2***	26.5±1.1	742.9±28.9	11.4±0.5
ATEC-40+TP	1,158.7±31.8	21.7±1.2††	749.1±37.2	12.6±0.7
ATEC-400	1,088.6±20.8***	24.5±0.8	663.6±26.3	11.8±0.4
ATEC-400+TP	1,206.8±10.5†	26.2±1.4	829.5±32.7	13.5±0.4

^a Immature castrated rats were administered with TP by subcutaneous injection for 10 days. One day after the final treatment, the accessory sex organs were removed carefully and weighed separately.
Symbols ^*, ^** and ^*** meant significant different in comparison between ORX group and test material group. ^*p<0.05; ^**p<0.01; ^***p<0.001.
Symbols ^†, ^†† and ^††† meant significant different in comparison between ORX group and test material group. ^†p<0.05; ^††p<0.01; ^†††p<0.001.
INT, intact; ORX, orchidectomy.