Table 2 Dose reduction index (DRI) values of combination treatments of imatinib (Ima) and metformin (Metf) in HCT15 cells.

Ima (uM)	1.25		2.5		5		10
	Metf	Ima	Metf	Ima	Metf	Ima	Metf	Ima
DRI at 0.25 mM Metf	2.33	11.2	2.54	5.92	3.36	3.56	4.33	2.11
DRI at 0.5 mM Metf	2.22	17.1	2.42	9.08	3	5.22	3.22	2.73
DRI at 1 mM Metf	2.11	26.14	1.91	12.25	2.09	6.51	1.88	3.03

DRI values denote how many folds of dose reduction are allowed for each drug due to synergism when compared with the dose of each drug alone.